How You Can Use PDGF Treatment with Both Sculptra and PRP
Skin rejuvenation is evolving—and patients are increasingly interested in results that look natural and last longer. One powerful way to achieve this is by combining PDGF (Platelet-Derived Growth Factor) therapy with Sculptra and PRP (Platelet-Rich Plasma).
While each treatment is effective on its own, using them together can create synergistic effects that stimulate collagen, boost healing, and visibly restore volume and radiance to the skin.
Here’s what you need to know about how PDGF works, and how it can be layered with both PRP and Sculptra for maximum skin rejuvenation.
Refresher: What Is PDGF?
PDGF (Platelet-Derived Growth Factor) is a natural protein found in your blood that plays a key role in healing and tissue regeneration. It’s one of the primary components in PRP, and is responsible for:
Activating fibroblasts (collagen-producing cells)
Stimulating collagen and elastin synthesis
Enhancing wound repair
Supporting healthy blood vessel formation
When injected into the skin, PDGF helps revitalize tissue from the inside out, making it an ideal complement to other biostimulatory treatments like PRP and Sculptra.
Using PDGF with PRP
PRP (Platelet-Rich Plasma) is a popular treatment that uses your body’s own platelets and growth factors to stimulate skin repair and regeneration. PDGF is one of the most active components in PRP—and by concentrating it or isolating it as part of the injection process, providers can enhance the rejuvenating effects.
Benefits of combining PDGF + PRP:
Boosts the healing response post-microneedling or laser
Speeds up recovery and reduces inflammation
Stimulates long-term collagen production
Improves texture, tone, and skin density
This combination is especially effective for treating acne scars, fine lines, under-eye crepiness, and overall skin dullness.
Using PDGF with Sculptra
Sculptra is a biostimulatory filler made of poly-L-lactic acid. Unlike traditional fillers, it doesn’t add volume instantly. Instead, it gradually stimulates your body’s own collagen production over several weeks or months.
When paired with PDGF, this process becomes even more powerful.
Benefits of combining PDGF + Sculptra:
Enhances collagen remodeling for more natural volume
Speeds cellular regeneration and skin renewal
Provides a more lifted, youthful appearance over time
May reduce the number of Sculptra vials or sessions needed
PDGF can either be injected directly or layered via PRP after Sculptra treatment to accelerate and enhance results—especially in areas like the cheeks, temples, jawline, and neck.
Why Combine All Three?
Used together, PDGF, PRP, and Sculptra create a regenerative trio that delivers visible results and long-term skin health. This combo is ideal for patients who want a natural-looking refresh without dramatic changes or downtime.
Your provider will tailor your treatment plan based on your skin condition, age, goals, and anatomy. Most clients see gradual improvements over a few months, with results lasting up to two years depending on the treatment plan.
What to Expect During Treatment
Each treatment is typically performed in a single session or series, depending on your goals.
Step 1: Blood is drawn and spun in a centrifuge to isolate PRP and PDGF.
Step 2: Sculptra is injected to stimulate deep collagen.
Step 3: PRP + PDGF is injected or applied topically post-treatment.
Mild swelling or redness is normal for a few hours. There is minimal downtime, and patients typically resume normal activities the same day.
Is This Treatment Right for You?
Combining PDGF with Sculptra and PRP is ideal for:
Clients seeking natural, long-term facial rejuvenation
Early volume loss or collagen depletion
Treating textural concerns like crepey skin or scarring
Enhancing results from microneedling, laser, or RF
Schedule a consultation to find out if this advanced regenerative combo is a fit for your skin goals.
Conclusion
PDGF is a powerful skin-renewing tool—especially when used alongside Sculptra and PRP. Together, they offer a holistic approach to collagen stimulation, healing, and subtle facial rejuvenation.
Interested in learning more? Book a consultation to create a treatment plan tailored just for you.
About Skin By Char’s technique
Char’s innovative injection techniques are on the cutting edge of Aesthetic Medicine allowing her to bring her patients the luxe experience they deserve. Her recent achievements include, but are not limited to, training with renowned medical institutes such as Dr. Paris with Ageless Aesthetics and Allergan Medical Institute (AMI), Galderma Aesthetic Injector Network (GAIN), Dr. Dhillon and Dr. Cetto with Master Injector Series, RevanceU and more,.
Have questions for Char? Fill out this form and she’ll get back to you!
